Towards biomarkers of human ageing — the ongoing EU FP7 project MARK-AGE
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چکیده
The Large-Scale Integrating Project MARK-AGE (“European Study to Establish Biomarkers of Human Ageing”; www.mark-age.eu) was launched in April 2008 and is carried out by 26 research groups from academia, SMEs and industry. The scientific background is the following: The rate of ageing in humans is not uniform, due to genetic heterogeneity and the influence of environmental factors. Age-related changes in body function or composition that could serve as a measure of “biological” age and predict the onset of age-related diseases and/or residual lifetime are termed “biomarkers of ageing”. Many candidate biomarkers have been proposed but their variability in crosssectional studies is considerable and no single measurement has so far proven to yield a useful biomarker of ageing on its own. Within the MARK-AGE project, we are conducting a population study (3,700 subjects) in order to identify a set of biomarkers of ageing which, as a combination of parameters with appropriate weighting, would measure biological age better than any marker in isolation. The range of candidate biomarkers being tested includes (a) “classical” ones for which data from several smaller studies have been published; (b) “new” ones, based on recent preliminary data, as well as (c) “novel” ones, based on recent research on mechanistic aspects of ageing, conducted by project participants. Bioinformatics will be used in order to extract a robust set of biomarkers of human ageing from the large amounts of data to be generated and to derive a model for healthy ageing. Session 1. Mechanisms of Ageing
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تاریخ انتشار 2012